Changes with age in the structure of fibromodulin in human articular cartilage
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چکیده
منابع مشابه
Changes with age in the glycosaminoglycans of human articular cartilage.
Human articular cartilage was obtained post mortem from the lateral femoral condyles of 30 subjects aged from under 1 to 70 years. Cryostat sections taken 0--100 micrometers and 900--100 micrometers deep to the cartilage surface were exhaustively extracted to recover the glycosaminoglycans (GAG). After fractionation by cellulose acetate electrophoresis and enzyme depolymerisation individual GAG...
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(ii) The Upper Middle Zone.-This contains rounded cells with branching irregular processes, often arranged in pairs. In addition to cytomembranes and mitochondria, many cells exhibit pinocytotic vesicles and large Golgi vacuoles, some of which open at the cell surface. The matrix immediately around each cell or between pairs contains fine fibres; the interfibrillar matrix between pairs often sh...
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15 صفحه اولAge-related changes in the structure of the proteoglycan subunits from human articular cartilage.
The proteoglycan of articular cartilage provides this tissue with its elastic properties, and the structure of these molecules plays a major role in determining the resilience of the tissue to compression. In the present paper we have shown that the structure of the proteoglycan subunits in human articular cartilage changes considerably between the fetus and the mature adult. These changes occu...
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A decrease in proteoglycan (Pg) content and disturbances in the collagen network have been reported in aging cartilage. This study aims to determine whether these changes are associated with proteolytic enzymes such as neutral metalloproteases. Eighty lateral tibial plateaus were collected from subjects after death. The age, topographical area, and lesion severity (macroscopic grading) of each ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 1996
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(96)80011-2